Yuji Nagayama Selected Research

Hyperthyroidism

1/2020	Graves' disease.
4/2018	Radiation-related thyroid autoimmunity and dysfunction.
10/2015	Animal models of Graves' disease and Graves' orbitopathy.
6/2011	Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model.
3/2011	Distinct role of T helper Type 17 immune response for Graves' hyperthyroidism in mice with different genetic backgrounds.
8/2010	Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice.
8/2009	Attenuation of induced hyperthyroidism in mice by pretreatment with thyrotropin receptor protein: deviation of thyroid-stimulating to nonfunctional antibodies.
6/2009	Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.
9/2008	Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice.
12/2007	The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells.

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Yuji Nagayama Research Topics

Disease

23	Hyperthyroidism 01/2020 - 03/2002
16	Neoplasms (Cancer) 08/2020 - 02/2003
16	Graves Disease (Basedow Disease) 04/2012 - 03/2002
11	Thyroid Neoplasms (Thyroid Cancer) 07/2022 - 11/2002
11	Thyroiditis 01/2020 - 09/2007
8	Autoimmune Diseases (Autoimmune Disease) 03/2011 - 04/2003
7	Hepatocellular Carcinoma (Hepatoma) 05/2007 - 05/2002
5	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 11/2011 - 09/2007
4	Carcinogenesis 01/2020 - 01/2014
4	Infections 03/2009 - 12/2002
3	Goiter 12/2007 - 03/2003
2	Papillary Thyroid Cancer 12/2018 - 11/2007
2	Hypothyroidism 01/2016 - 12/2007
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2015 - 03/2008
2	Hyperplasia 08/2005 - 11/2004
1	Fetal Diseases (Embryopathy) 01/2020
1	Hypoparathyroidism 01/2020
1	Inflammation (Inflammations) 01/2020
1	Graves Ophthalmopathy 01/2020
1	Anaplastic Thyroid Carcinoma 03/2017
1	Neoplasm Metastasis (Metastasis) 01/2016
1	Neurologic Manifestations (Neurological Manifestations) 10/2015
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2015
1	Genomic Instability 03/2014
1	Adenoma (Adenomas) 01/2014
1	Sialadenitis 09/2011
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 06/2009
1	Nonautoimmune Hyperthyroidism 12/2007
1	Lymphopenia (Lymphocytopenia) 09/2007

Drug/Important Bio-Agent (IBA)

26	Thyrotropin Receptors (Thyrotropin Receptor)IBA 01/2020 - 03/2002
15	AutoantibodiesIBA 01/2020 - 03/2002
13	AntibodiesIBA 12/2018 - 03/2003
9	CytokinesIBA 01/2014 - 02/2003
8	IodineIBA 01/2020 - 12/2007
7	Thyroglobulin FDA Link 01/2020 - 12/2007
7	AutoantigensIBA 04/2018 - 06/2003
6	Proteins (Proteins, Gene)FDA Link 08/2020 - 05/2003
6	anti-thyroglobulinIBA 12/2018 - 09/2008
6	Thyroid-Stimulating ImmunoglobulinsIBA 12/2007 - 03/2002
5	EpitopesIBA 08/2009 - 03/2002
4	Iodide Peroxidase (Deiodinase)IBA 12/2018 - 12/2007
4	Aldehyde DehydrogenaseIBA 01/2018 - 08/2013
4	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 01/2004
4	AntigensIBA 06/2011 - 12/2002
3	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 03/2014 - 08/2005
3	Interleukin-4 (Interleukin 4)IBA 11/2009 - 04/2003
3	Drinking WaterIBA 11/2009 - 09/2007
2	Pharmaceutical PreparationsIBA 01/2020 - 01/2015
2	Cadherins (E-Cadherin)IBA 01/2020 - 08/2013
2	VimentinIBA 01/2020 - 08/2013
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2014 - 08/2013
2	Interleukin-17 (Interleukin 17)IBA 11/2011 - 03/2011
2	InterferonsIBA 11/2011 - 10/2002
2	SodiumIBA 03/2009 - 09/2008
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2007 - 07/2006
2	Thyroxine (Levothyroxine)FDA LinkGeneric 03/2003 - 03/2002
2	Messenger RNA (mRNA)IBA 11/2002 - 05/2002
2	LigandsIBA 11/2002 - 05/2002
1	Cisplatin (Platino)FDA LinkGeneric 07/2022
1	Sorafenib (BAY 43-9006)FDA Link 07/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2022
1	Mitochondrial DNA (mtDNA)IBA 08/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Antithyroid Agents (Antithyroid Drugs)IBA 01/2020
1	Thyroid HormonesIBA 01/2020
1	Long-Acting Thyroid Stimulator (LATS)IBA 04/2018
1	PlasticsIBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	IsoenzymesIBA 03/2017
1	Small Interfering RNA (siRNA)IBA 03/2017
1	cyclopamineIBA 03/2017
1	Colloids (Colloid)IBA 01/2016
1	Interferon Regulatory FactorsIBA 11/2015
1	Insulin (Novolin)FDA Link 11/2015
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 10/2015
1	Indicators and Reagents (Reagents)IBA 01/2015
1	CarcinogensIBA 01/2014
1	Transforming Growth Factor-beta Type II ReceptorIBA 01/2014
1	Surface Antigens (Surface Antigen)IBA 08/2013
1	AldehydesIBA 08/2013
1	Interferon gamma ReceptorIBA 11/2011
1	Dihydrotachysterol (AT 10)IBA 09/2011
1	Interleukin-10 (Interleukin 10)IBA 06/2011
1	Amino Acids FDA Link 08/2010
1	Interferon-gamma (Interferon, gamma)IBA 11/2009
1	Protein Subunits (Protein Subunit)IBA 08/2009
1	TNF-Related Apoptosis-Inducing LigandIBA 03/2009
1	Green Fluorescent ProteinsIBA 03/2009
1	insulin B (9-23)IBA 03/2008
1	Biological ProductsIBA 11/2007
1	Cyclin D1IBA 11/2007
1	IodidesIBA 09/2007

Therapy/Procedure

8	Therapeutics 07/2022 - 12/2003
2	Immunotherapy 05/2007 - 07/2006
2	Intramuscular Injections 03/2003 - 03/2002
1	Tissue Expansion 01/2020
1	Transjugular Intrahepatic Portasystemic Shunt 09/2011
1	Neck Dissection (Radical Neck Dissection) 03/2009
1	Thyroidectomy 12/2007